Monday, January 23, 2017

Heart has its own defence

Hearts are made to be broken, so said Oscar Wilde.  Human heart handles emotional trauma in the classical  way with  time as the healer.  Pain slowly gets  relegated to the dark recess of memory and even if  it surfaces at times one  would have  by then learned the art of dealing with it. 

Work by BruceBlaus Wikipedia 



Now about physical damages. Medical world has  amazing ways of repairing and constructing damaged heart- bypass surgery, valve replacement, heart transplantation etc are easily said and as easily done too. Heart is a relentless machine.  Per day statistics runs roughly like this- about 100,000 beats which facilitates the pumping of  about 2000 gallons of oxygen rich blood through the aorta to reach every nook and corner of the body.  Heart's own needs are taken care of by the  left and right coronary arteries. These arteries divide and subdivide into smaller and smaller  branches  and  reach every fibre of the cardiac muscle. 


It has now been discovered that coronary arteries respond with ingenuity when confronted with blockages in their blood circulation network. They immediately presses  into action  dormant  channels called collateral  channels. Now collateral plumbing system is laid down at birth to be used in emergency.  When pressed into action  they bypass the blockage, reach blood and nutrients to the required spot.  With continued usage collateral channels  grow bigger and stronger and can restore  upto 40% efficiency.  In rare occasions  even brand new channels might be opened.  Dr Rubanyi who works in the area of cardiovascular therapeutics  is confident that heart can be coaxed to grow new blood vessels under duress.  Towards this end it is necessary to know under what circumstances collateral blood vessels  become active. 

There are indications that  vigorous physical exercise could be one of the factors that push blood into dormant collateral channels. But then there are patients  for whom even minimal physical exertion is a big NO NO. "Hence the search "  Dr Rubanyi says  "for the right combination of designer proteins, genes or cells to push the heart to expand its collateral network."  

References:
1. The heart therapy by  Gabor Rubanyi  Scientific American  January 2017