Friday, June 14, 2013

Nature (still) Leads


With products  perfected over billions of years (of painstaking evolution), to suit  every tiny creature, in accordance with its unique  life style,  Nature never  ceases to amaze us. In her ever open house   unlimited treasures are  flung around with such joyous abandon   for us  to see,  to feel,  to experience and to learn and above all to mimic.  Two recent  research reports   reiterate this undeniable  truth further.

Karp etal (1) in their recent paper  discuss  a marvelous  biomedical adhesive, inspired by  Pomphorhynchus laevis,   indeed  too big a name for  a tiny parasitic  that infects fresh water fish.  But  once you realize how cleverly   it uses its head ( both  literally and figuratively ), you will concede the name. Since the parasite  has no hands nor feet to cling to its host, it uses  its proboscis, the elongated part of its head. Proboscis is an interesting word and  its genesis is from the Greek word proboscis( προβοσκίς ) which means, somewhat like move  forward to feed.  The clever  worm inserts its head which as an array of sharp nanotips into the host’s intestinal wall, the outer cover of the nanotips then swell, thus ensuring not only a well cushioned anchoring, but also smooth back tracking, whenever necessary.
  
Inspired and excited by this and the umpteen possibilities in soft tissue repair and restoration,   Karp's team    built a prototype. A  simple  elastomer sheet  with polystyrene spikes each with a  sheath of poly( styrene)- poly(acrylic acid) block copolymer. Acrylic acid is extremely hydrophilic and sticky  organic molecule; and poly (acrylic acid) is even more so.  In fact  poly (acrylic acid) is the predominant segment in  most of the super absorbent polymers.  So the sheath takes up water, swells and sticks in place.    Now imagine the immediate   possibilities : first  medicating the hydrogel sheath, next controlling the pore size of the hydrogel for controlled  drug delivery, then  built-in mechanism for timed hydration and subsequent dehydration of the sheath so that the spike naturally falls of like a dry leaf.   .

Arthropods (houseflies, ants, bees etc.) are invertebrates with segmented bodies.  This  tribe,  has been taunting mankind for long,   with their  compound eye. A Compound eye is made up  of a  cluster of small simple eyes  (singular ommatidium, plural ommatidia).    Ommatidia may lack the fine resolution  of the mammalian eye,  but  it bestows  a  panoramic view with unlimited depth of vision low aberration and  above all instantaneous ability to detect motion,  features extremely desirable in cameras.  But then you need  hemispherically configured   imaging elements to achieve this.   Even the latest digital cameras work on principles of  planar sensors and conventional optics.   

  
                                                         Ommatidia of the arthropod


The team demonstrates ”how a camera can accurately and simultaneously render pictures  of multiple objects in a field of view , even at widely different angular positions and distances.”A  cross disciplinary global team has surmounted the difficulties(2) by combining the advantages of  stretchable electronics with hemispherical photodetector arrays.   The prototype  digital camera has tiny lenses molded out of a flexible sheet of  poly (dimethylsiloxane, PDMS for short), connected to a  stretchable  mesh  of silicon photodiodes and blocking diodes appropriately placed and connected with  whiskers of metal embedded polyimides. Each Microlens  with its own photodetector and electrical connections  is equivalent to an  ommatidium and the manmade ommatidia might roughly look like the  bubble wrap, but several orders of magnitude smaller.  A perforated black silicon cap over the microlens array and a black support below the assembly effectively cuts off stray light. The team has demonstrated ”how a camera can accurately and simultaneously render pictures  of multiple objects in a field of view , even at widely different angular positions and distances.”


1. "A bio-inspired swellable microneedle adhesive for mechanical interlocking with tissue". Nature Communications  4 (1702). April 2013.

2. Digital cameras with designs  inspired by the arthropod eye. Song et al Nature  , 497, 95-99. 2nd May 2013



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